Abstract
Effects of thiazide administrbtion on calcium and phosphate metabolism are investigated in 16 recurrent stone formers associated with hypercalciuria. On the basis of 5 to 30 months with thiazide, the following conclusions are obtained. 1. Stone progression ceases at least 75% of patients who are taking thiazide on a regular basis. 2. In addition to the hypocalciuric action, thiazide reduce urine phosphate and uric acid excretions but elevate oxalate excretion. 3. While serum clacium decreases, serum phosphate and uric acid increase. 4. A good correlation between an increment of serum phosphate and a decrease in 1, 25(OH)2D3, or a decrease in serum clacium and an elevation of serum PTH may provide a clue to the pathophysiology of idiopathic hypercalciuria. Although thiazide is effective in hypercalciuric patients, a watchful observation should be required in those biochemical changes during the long-term use of the agent.
