正常および各種疾患における血漿レニン基質
―食塩および各種薬剤投与による影響―
1987 年 29 巻 10 号 p. 1241-1247
詳細
1987 年 29 巻 10 号 p. 1241-1247
The present study showed the plasma renin substrate concentration (PRS) of various diseases, i, e. essential hypertension, hyperaldosteronism, Cushing's syndrom, isolated ACTH deficiency syndrom, liver cirrhosis and nephrotis. For the next experiment, the effects of various medicine were examined, i. e. furosemide or captopril were administered to the essential hypertensive patients and methylprednisolon was infused to the nephrotic patients with edema. In some of the normotensive subjects, sodium was restiricted and after that sodium was loaded, PRS was measured in before and after these procedures. PRS values were 4144.2±201.5 ng/ml (n=20) in normal subjects and 3720.3±156.6 ng/ml (n=21) in essential hypertensive patients. These values were no significant difference. Primary aldosteronism showed the normal value. On the other hand, PRS levels of Cushing's syndrome were over 5000 ng/ml and these values were decreased after an adrenalectomye The values of liver cirrhosis (2094.6±455.5 ng/ml) were almost half of the normal values. The patients of isolated ACTH deficiency syndrome also showed low level. PRS level of nephrotic syndrome was low but this value was increased with the improvement of an edema. Both acute and chronic administrations of captopril led the PRS level to decline, but these values recovered abruptly after cessation of the medicine. The sodium load caused the PRS level to increase and the plasma renin activity (PRA) to decrease. On the other hand, the increase of sodium excretion due to furosemide responded with the decreased PRS and the increased PRA. By the infusion of methyl-prednisolon 1000 mg for the puls treatment in nephrotic syndrome, the PRS was increased significantly but the PRA was decreased. Although there were no significant differences of the PRS level between normal subjects and hypertensive patients, this value was decreased significantly in the patients of liver cirrhosis. By the administration of a medicine or sodium, the PRS level changed to the opposite direction in the PRA.
