慢性腎不全患者および腎移植患者におけるHelicobacter pylori (Hp) とPepsinogen I/II 比の重要性

抄録

Helicobacter pylori (Hp) infection is thought to play an important role in for the pathogenesis of atrophic gastritis and even gastric carcinoma. The ratio of Pepsinogen I/II(PI/II)also shows good correlation with atrophic gastritis and gastric ulcer. Since many hemodialysis (HD) and renal transplantation patients suffer from gastrointestinal problems, we investigated the importance of Hp infection and PI/II in these patients. Serum Hp IgG was measured by EIA. Pepsinogen titer was measured with antipepsinogen antibody-bearing beads and anti-pepsinogen antibody. Hp positive HD patients accounted for 50.7% of the subjects. Of the renal transplantation patients, 23.5%were positive with lower values than the HD patients. The value of PI/II in all patients with a high Hp positive titer also was low (under 3).In conclusion, serum IgG antibody to Hp and PI/II exhibit good correlation and both are useful for the diagnosis of atrophic gastritis in chronic renal failure.