Abstract
In 244 cases treated by subcapsular prostatectomy during the period from April 1975 to December 1985, whole tissue specimens were prepared by a step section technique to examine them histopathologically in accordance with the handling agreement for prostatic cancer presented by the Urologic Society of Japan. The degree of differentiation, clinical stage of hte disease, the size of the lesion and the distance to the margin were determined. Incidental carcinoma was found in 35 cases (14.3%), which increased with age.
There were 21 cases of stage A1 and 14 cases of A2. Diffuse proliferation was found in 4 cases. Isolate dcarcinomatous focus was observed in 40 sites, and well, moderately, and poorly defferentiated adenocarcinoma in 33, 3 and 4 sites respectively. The maximum diameter of cancer wa below 5mm in 80%, while the distance from the center of the carcinomatous focus to the surgical margin was within 3.5mm in 905. Seven cases had plural lesions.
These lines of evidence mentioned above may support carcinogenesis from the subcapsular region as well as multicentric origin of cancer.
