The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
LOCALIZATION OF α1-ADRENOCEPTORS IN HYPERTROPHIED PROSTATE
Nobuo MoriyamaKazuki KawabeKozo HamadaKiyoshi KimuraIsao MurahashiYoshio Aso
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1991 Volume 82 Issue 1 Pages 117-121

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Abstract

In order to determine the localization of α1-adrenoceptors in human hypertrophied prostates, in vitro autoradiography was performed on the frozen specimens from 13 enucleated hypertrophied prostates with [125I]-HEAT (iodo-2-[β-(4-hydroxyphenyl)-ethylaminomethyl] tetralone) and [3H]-prazosin. In vitro autoradiograms showed macroscopically the specific binding site on the areas seemed to the nodular area for [125I]-HEAT, but not so clear specific binding sites for [3H]-prazosin. Microscopic autoradiograms seemed to show binding sites located mainly on the interstitium beneath the gland, and partly on the basement membrane and epithelium of the prostatic gland. Further studies are needed to show clearer specific binding sites of α1-adrenoceptors.

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© Japanese Urological Association
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