PHARMACOLOGIC CHARACTERISTICS OF HUMAN NEUROGENIC BLADDER

Response to KCl, Carbachol, ATP and CaCl₂

Abstract

Pharmacologic characteristics of the human neurogenic bladder to KCl, carbachol, ATP and CaCl₂ was investigated in vitro in comparison with the control bladder. Patients with neurogenic bladder underwent augumentation enterocystoplasty because of low bladder compliance or uninhibited contraction which resulted in urinary incontinence and/or vesicoureteral reflux.
1. There was no difference in the contractile strength to KCl between the neurogenic bladder and the control.
2. The contractility (both contractile strength and the value of ED₅₀) to carbachol was than in the control.
3. The contractile strength of the neurogenic bladder to ATP showed greater efficacy than that of the control bladder.
4. The contractility of the neurogenic bladder (contractile strength and the value of ED₅₀) to CaCl₂ was significantly greater than that of the control.
5. In the neurogenic bladder there was no correlation between pharmacological responsiveness and the clinical parameters including the data of cystometry.
In conclusion, the human neurogenic bladder demonstrated supersensitive responses to carbachol, ATP and CaCl₂.