The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
KIDNEY PRESERVING SURGERY FOR RENAL CELL CARCINOMA IN PATIENTS WITH A SOLITARY KIDNEY OR BILATERAL TUMORS
With Special Regard to Indication and Limitation of Enucleation
Makoto HataShiro BabaMasaaki TachibanaNobuhiro DeguchiSeido JitsukawaHiroshi Tazaki
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1991 Volume 82 Issue 3 Pages 412-419

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Abstract

We performed kidney preserving surgery for renal cell carcinoma in 10 patients with a solitary kidney or bilateral tumors. Two had cancer in a solitary kidney (contralateral kidney was nephrectomized for benign disease) and 8 had bilateral renal tumors, 3 and 5 of the latter 8 patients being asynchronous and synchronous, respectively.
The kidney preserving surgery included partial nephrectomy in 3 patients and enucleation in 7 patients and was performed in situ and ex vivo followed by renal autotransplantation in 4 and 6 patients, respectively.
Of the 10 patients, 4 are still alive after 2 years and 11 months-5 years and 6 months. Death occurred in 6 patients. Excluding one non-resectable patient and 2 patients of non-cancer death, 3 patients survived for 3 years-8 years and 8 months. The 10 patients, excluding one non-resectable, showed actuarial survival rates of 89, 89 and 63.3% for 1, 3 and 5 years, respectively, and excluding patients of non-cancer death, the above rates were 100, 100 and 85.7%, respectively.
Postoperative local recurrence was found in 1 of 3 patients of partial resection and 2 of 7 patients of enucleation, and the latter 2 patients were those who had synchronous bilateral tumors and underwent renal autotransplantation following enucleation of a number of tumor nodules from seemingly less involved kidneys and contralateral radical nephrectomy; recurrence in the grafted kidney was already observable in the early postoperative period, which indicated re-growth of the residual tumor rather than recurrence.
Based on our experiences kidney preserving surgery, in particular enucleation, was proved to be an excellent surgical approach in that it could provide patients with better survival with high QOL, in spite of the limited radicality in the case of multiple tumors.

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