S100a₀ PROTEIN AND CREATINE KINASE ISOZYMES (CK-B & CK-M) IN SERUM AND URINE MIGHT BE USEFUL MARKERS FOR NON SPECIFIC TISSUE DAMAGES BY EXTRACORPOREAL SHOCKWAVE LITHOTRIPSY (ESWL)

Abstract

In order to demonstrate that the extracorporeal shockwave lithotripsy (ESWL) for urolithiasis causes a renal damage, we immunoassayed S100a₀ protein and creatine kinase isozymes (CK-B & CK-M) in the serum and urine from patients with renal stone (N=21) and those with ureteral stone (N=18) before and after ESWL. S100a₀ protein and CK-B, which are localized in the proximal renal tubules at relatively high concentrations, were enhanced more or less both in the urine and serum samples after the treatment in both groups of patients. Since CK-M, which is mainly localized in muscle tissue, also increased in both groups of patients, S100a₀ protein and CK-B may be derived not only from kidney, but also from muscle tissues.