傍糸球体細胞腫の1例 免疫組織化学的染色, 電顕, in situ hybridization による解析

橋本 恭伸; 中沢 速和; 奥田 比佐志; 伊藤 文夫; 鬼塚 史朗; 木原 健; 鈴木 万里; 前田 佳子; 東間 紘

doi:10.5980/jpnjurol1989.89.907

A JUXTAGLOMERULAR CELL TUMOR

Analysis of Immunohistochemistry, Electron Microscopy and In Situ Hybridization

Yasunobu Hashimoto, Hayakazu Nakazawa, Hisashi Okuda, Fumio Ito, Shiro Onizuka, Ken Kihara, Mari Suzuki, Yoshiko Maeda, Hiroshi Toma

Author information

Yasunobu Hashimoto
Department of Urology, Tokyo Women's Medical Collge
Hayakazu Nakazawa
Department of Urology, Tokyo Women's Medical Collge
Hisashi Okuda
Department of Urology, Tokyo Women's Medical Collge
Fumio Ito
Department of Urology, Tokyo Women's Medical Collge
Shiro Onizuka
Department of Urology, Tokyo Women's Medical Collge
Ken Kihara
Department of Urology, Tokyo Women's Medical Collge
Mari Suzuki
Department of Urology, Tokyo Women's Medical Collge
Yoshiko Maeda
Department of Urology, Tokyo Women's Medical Collge
Hiroshi Toma
Department of Urology, Tokyo Women's Medical Collge

Keywords: juxtaglomerular cell tumor, in situ hybridization, renin

JOURNAL FREE ACCESS

1998 Volume 89 Issue 11 Pages 907-910

DOI https://doi.org/10.5980/jpnjurol1989.89.907

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Abstract

We present a case of juxtaglomerular cell tumor measuring 8mm in diameter in the right kidney, The hypertension was cured and plasma renin activity returned to normal level following tumor resection with partial nephrectomy. We studied histopathologic, electron microscopic, and immunohistochemical findings of the tumor. The majority of tumor cells stores renin granules in cytoplasm. In situ hibridization comfirmed us that the most tumor cells produce renin. We use the digoxigenin labeled 0.6-kb length RNA probe of human renal renin. the specificity was analyzed by competition assay (1:50).

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