The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
A CLINICAL STUDY OF SECONDARY OSTEOPOROSIS INDUCED BY ENDOCRINE THERAPY FOR PROSTATE CANCER
Akira FurutaShuichi YanadaAkitoshi TakizawaShinya IwamuroMasayasu SuzukiKazuya TashiroTakashi HatanoYukihiko Oishi
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2000 Volume 91 Issue 7-8 Pages 573-578

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Abstract

(Purpose) There is one of the big problems that endocrine therapy for prostate cancer causes to induce secondary osteoporosis. The risk factors and future treatments for osteoporosis were investigated.
(Materials and Methods) 31 patients treated with luteinizing hormone releasing hormone agonists (LHRH-a) or combination of chlormadinone acetate (CMA) and LHRH-a, and 19 patients with no treatments for prostate cancer were included in the analysis. Lumber spine bone mineral density (BMD) was measured by quantitative computed tomography.
(Results) Aging had much influence on decreases of BMD than the other risk factors (p<0.01). There were statistically decreases of BMD in the patients with CMA+LHRH-a compared with no treatments (p<0.05). Adrenal androgen which had an important role of maintenance in BMD was statistically decreased by the administration of CMA (p<0.01).
(Conclusions) Measurement of BMD before endocrine therapy is necessary for the patients with prostate cancer. It is important for the patients with decreases of BMD that CMA is not combined or the therapy for osteoporosis is preventively employed.

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