The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
CENTRAL AND PERIPHERAL NERVE DISORDER INDUCED BY INTERFERON α THERAPY FOR RENAL CELL CARCINOMA
Karen KatoSo OmoriTakanao TanakaSunao KomatsuTakashi SeoJun SugimuraRyuichirou KondaEtsuko YamazakiTomoaki Fujioka
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2003 Volume 94 Issue 7 Pages 701-704

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Abstract

Interferon α (IFN-α) therapy was conducted for a male patient aged 70 years old, who underwent a two-stage radical nephrectomy for bilateral renal cell carcinoma with multiple pulmonary metastasis. He was hospitalized due to leg weakness and disorientation 45 days after this treatment was started. We discontinued INF-α therapy immediately after neurologists indicated the disorder of the central and the peripheral nervous systems induced by the administration of this cytokine. Steroid pulse therapy was effective to resolve the patient's neurological symptoms. To our knowledge, this is the first case of the side effects on both central and peripheral nervous systems by IFN-α therapy for renal cell carcinoma.

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