The Journal of Protozoology Research
Online ISSN : 2434-7027
Print ISSN : 0917-4427
Past achievements, current situation and future challenges for vaccine development against Cryptosporidium parvum and C. hominis infections
Ragab M. FereigHanan H. AbdelbakyYoshifumi Nishikawa
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ジャーナル フリー

2018 年 28 巻 1-2 号 p. 39-52

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In developing and developed countries, infection with Cryptosporidium species is considered as a disease of major health and economic concerns. Among the several identified species, C. parvum (zoonotic and anthroponotic agent) and C. hominis (anthroponotic agent) are the most important species, inducing diarrhea in humans and calves. Fatality of cryptosporidiosis in AIDS patients and immunocompromized individuals engender the importance of immune response against such disease. As most of parasitic diseases, the vaccine development against Cryptosporidium is still problematic because of great complexity of developmental parasitic stages. However, the immuno-prophylactic and therapeutic approaches have exhibited promising results in mouse and cattle models. Both cellular and humoral immunities are required for conferring protective immunity in the tested animal models. Recombinant DNA and protein based on glycoprotein Cp15 and P23 are the predominantly evaluated candidates and the mostly successful vaccine antigens. This review highlighted the previous studies with successful vaccine antigens, summarizes the current challenges and limitations, and suggests solutions for future application in vaccine development against Cryptosporidium infection.

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© 2018 National Research Center for Protozoan Diseases, National University Corporation Obihiro University of Agriculture and Veterinary Medicine
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