Host: The Japanese Pharmacological Society
Name : The 97th Annual Meeting of the Japanese Pharmacological Society
Number : 97
Location : [in Japanese]
Date : December 14, 2023 - December 16, 2023
With advances in DNA sequencing and various ‘omics’ technologies, it has becomepossible to capture changes in immune cells through the analysis of biologicallyactive substances such as cytokines and chemokines, as well as T- and B- cellreceptor sequence analysis in various pathological conditions and drugresponses. Furthermore, technological advances in the single cell level havemade it possible to understand the dynamic changes in immune cells in detail. Inaddition, it has been suggested that the immune responses activated through drugand HLA interaction play key roles in drug-induced skin hypersensitivity andhepatotoxicity. HLA class I molecules are associated with drug eruptions such asStevens-Johnson syndrome, and class II molecules with hepatotoxicity. In cancertreatment, it is becoming clear that the immune environment within cancertissues and throughout the body is important not only for cancer immunotherapybut also for the responsiveness of other anticancer drugs and radiation therapy.Changes in immune responses during the onset, remission, and progressionprocesses of various diseases have not been completely analyzed until now, butdevelopment of immunopharmacogenomics will certainly help to elucidate thesechanges.
