2010 Volume 70 Issue 6 Pages 333-341
The physicochemical and rheological properties of O/W type emulsions were investigated and evaluated by multiple light scattering analysis to enable topical drug formulation under various accelerated storage conditions (25-50°C). The multiple light scattering analyzer (Turbiscan®) could quickly determine the physicochemical properties of the emulsions and measure initial concentrated O/W emulsions. This multiple light scattering analyzer could accurately estimate the physicochemical differences in emulsions from changes in their initial backscattering. Physicochemical stability, such as agglomeration/coalescence/creaming of the emulsions, was especially strongly related to their viscosity and droplet size. It was concluded that multiple light scattering analysis of O/W emulsions could be a novel and effective means of predicting of physicochemical stability in early drug formulation development.
