2007 年 19 巻 4 号 p. 223-225
The purpose of this study was to investigate the relationships between dyspnea, respiratory muscle strength, and ventilatory failure in patients with amyotrophic lateral sclerosis (ALS). A cross-sectional study, based on patients' medical records, was performed at a primary care hospital in Japan. Twenty-five patients diagnosed with ALS who received care as outpatients or inpatients were included in this study, and patients' characteristics, dyspnea on the subscale of the revised ALS Functional Rating Scale, sniff nasal inspiratory pressure (SNIP), an indicator of respiratory muscle strength, and arterial carbon dioxide pressure (PaCO2) were selected as main outcome measures. All data were collected from patients' medical records. For patients with dyspnea, SNIP was significantly lower and PaCO2 tended to be higher than in patients without dyspnea. There were no significant differences in both bulbar symptoms and types of disease onset between the patients with and without dyspnea. In patients with ALS, it is suggested that dyspnea reflects respiratory muscle weakness and ventilatory failure. For the assessment of respiratory function in patients with ALS, it may be important to evaluate dyspnea in addition to SNIP and PaCO2.