重イオンマイクロビームを用いた線虫Cエレガンスの放射線応答の研究

東谷 篤志; 森 ちひろ; 杉本 朋子; 太齋 久美子; 坂下 哲哉; 舟山 知夫; 柿崎 竹彦; 浜田 信行; 和田 成一; 小林 泰彦

doi:10.11513/jrrsabst.2006.0.79.0

The 49th Annual Meeting of The Japan Radiation Research Society

Session ID : WS8-9

DOI https://doi.org/10.11513/jrrsabst.2006.0.79.0

Conference information

Host: The Japan Radiation Research Society

Progress of Radiation Research Using Microbeam

Study of biological responses to heavy-ion microbeams in the nematode C. elegans<I/>

*Atsushi HIGASHITANI, Chihiro MORI, Tomoko SUGIMOTO, Kumiko DAZAI, Tetsuya SAKASHITA, Tomoo FUNAYAMA, Takehiko KAKIZAKI, Nobuyuki HAMADA, Seiichi WADA, Yasuhiko KOBAYASHI

Author information

*Atsushi HIGASHITANI
Labo. of Genomic Reproductive Biology, Grad. Sch. of Life Sci., Tohoku Univ.

Chihiro MORI
Labo. of Genomic Reproductive Biology, Grad. Sch. of Life Sci., Tohoku Univ.

Tomoko SUGIMOTO
Labo. of Genomic Reproductive Biology, Grad. Sch. of Life Sci., Tohoku Univ.

Kumiko DAZAI
Labo. of Genomic Reproductive Biology, Grad. Sch. of Life Sci., Tohoku Univ.

Tetsuya SAKASHITA
Microbeam Radiation Biology Group, Japan Atomic Energy Agency

Tomoo FUNAYAMA
Microbeam Radiation Biology Group, Japan Atomic Energy Agency

Takehiko KAKIZAKI
Microbeam Radiation Biology Group, Japan Atomic Energy Agency

Nobuyuki HAMADA
Microbeam Radiation Biology Group, Japan Atomic Energy Agency

Seiichi WADA
Microbeam Radiation Biology Group, Japan Atomic Energy Agency

Yasuhiko KOBAYASHI
Microbeam Radiation Biology Group, Japan Atomic Energy Agency

Corresponding author

Keywords: apoptosis, heavy ion, microbeam

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Published: 2006 Received: - Available on J-STAGE: March 13, 2007 Accepted: - Advance online publication: - Revised: -

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Abstract

The nematode Caenorhabditis elegans is an experimental model organism used to study several genetic systems for development, neuronal network, locomotion and reproduction. Its genome and cell lineage have been determined, and lots of genetic mutants have been isolated. We are now attempting to study the tissue-specific effects of ionizing radiation on the germline cells using the heavy-ion microbeam irradiation apparatus at TIARA. In this presentation, we show the experimental procedures and the results of cell-cycle arrest and apoptosis in the germline cells following heavy-ion microbeam irradiation, and discuss the future experiment

Corresponding author

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