To address the issue involved in the comparison of the dose of microbeam experiments with that of broadbeam ones.

Abstract

Low dose or low fluences of ionizing radiation induces Poisson distribution of the exposure dose in a cell population (macro-scale). On the other hand, microbeam irradiation technique makes one-cell exposure with an exact quantity possible to do. However, there are many problems on understanding common or different points between macro and micro scale for radiation biology, because of a bystander response and an application limit of dose (J/kg). The present paper will discuss on these points.