Adhesion of rat platelets and lymphocytes on polystyrene/polyamine comb type copolymers (SA copolymers) was investigated. Shape changes of attached platelets can be controlled from “negligible” to “marked” by varying the mode of “microphase separation” of SA copolymer surfaces. Adhesivity of platelets and lymphocytes can be controlled, individually, by coating SA copolymer surfaces with plasma protein, suggesting that separation of lymphocytes from platelets could be achieved on an appropriate SA copolymer surface adsorbed with plasma protein. We assume that the “microphase separated” structure of SA copolymer may regulate the adhesion and shape change of cells through its effect on a redistribution of glycoproteins present at the plasma membrane of platelets.
