Abstract
Simple polyethylene films and collagen-polyethylene composite films were implanted into rats subcutaneously and the respective rates of tumorigenesis were compared. After 24 months of observation, the tumorigenesis rate for collagen-polyethylene composite (14/80, 17.5%) was significantly lower than that for simple polyethylene (31/80, 38.8%). From these results, collagen-plastic composite materials seem to be effective for controlling foreign body reaction and for suppressing tumorigenesis reaction.
