Abstract
Therehave been various reports on the effects of the vitamin E-modified dialyzer CL-EE. These effects include a decrease in the amount of oxidized LDL and cytokines. We investigated variations in the antioxidative activity of vitamin E during extracorporeal circulation in vitro experiments and we studied the influences of vitamin E on erythrocyte membrane lipids and production of advanced glycation end products (AGEs). The antioxidative properties of vitamin E were evaluated by measuring of the amount of plasma lipid peroxide production after proteins were adsorbed into dialysis membranes of a CL-EE minimodule that was circulating human blood. Variations were not observed, either before or after the adsorption of protein and that showed vitamin E inhibited the production of lipid peroxides. It was revealed vitamin E-modified dialyzer CL-EE inhibited the production of erythrocyte membrane lipid peroxides and AGEs. As mentioned above, CL-EE inhibits not only the production of plasma lipid peroxides, but also the production of erythrocyte membrane lipid peroxides and AGEs. Furthermore, CL-EE is expected to reduce prolonged complications.
