1976 年 5 巻 6 号 p. 321-327
The rapid decrease in hematocrit (Ht) and total protein (Tp), gradual increase in central venous pressure, and peripheral circulatory insufficiency such as impossibility of standing up, poor appetite, anuria or oliguria and constipation or mucous feces were the most serious physiological problems in recent total artificial heart (AH) animal experiments. For these phenomena, a phsiological hypothesis was presented by authors under the consideration of that too much cardiac output for animal might induce such phenomena.
As the results of animal experiments with goat, the following finidings were obtained.
(1) High cardiac output of AH causes a marked decrease in Ht and Tp, as well as peripheral circulatory insufficiency.
(2) By maintaining the cardiac output within the range of 80 to 100ml/Kg/min. during the experiments, maximum and average survival days of the goats replaced totally with AH were markedly prolonged, from 10 days to 54 days and from 4.5 days to 30.5 days, respectively. And the surviving condition of these goats were almost normal physiologically and pathophysiologically.
(3) As conclusion, it became obvious that the cardiac output was one of the most important physiological parameter for control of the circulatory system.