合成ポリ・α・アミノ酸膜による尿路再建術

抄録

Reconstruction of the damaged urinary tract is one of the most important problems in clinical urology. Implantation of artificial prosthesis of the urinary bladder has been unsuccessful, so that intestines and bowels have been used for this purpose.
To develop the reconstruction synthetic poly-alphaaminoacids membranes were investigated. These membranes were as follows:
1. Poly-γ-Methyl-L-Glu.
2. Copoly (L-Leu, γ-Methyl-L-Glu, 1:3)
3. Copoly (L-Leu, γ-Methyl-L-Glu, 3:4)
4. Copoly (γ-Benzyl-L-Glu, γ-Methyl-L-Glu, 1:2)
5. Copoly (γ-Benzyl-L-Glu, γ-Methyl-L-Glu, 1:5)
6. Poly-ε-Benzyloxycarbonyl-L-Lysine.
These membranes were implanted on the back of dd-strain mice and their biodegradation was examined. Among them Poly-ε-Benzyloxycarbonyl-L-Lysine membrane was disappeared most rapidly within a month. The reconstruction was done by this membrane. The upper half of the bladder in rabbits was excised and the bladder substitute was sutured with catgut. The surviving animals were sacrificed 1, 2, 3 or 4 weeks after the operation and the regeneration was examined histologically and urologically. Almost after one month the bladder was completely replaced with regenerated bladder tissues.