人工肝臓の研究―ビリルビンの除去を中心として

抄録

Ionex is a new cationic resin specially designed to adsorb bilirubin in the blood. It ionically binds conjugated and unconjugated bilirubin and removes bilirubin fran the blood but the addsoption of albumin and other fraction of plasma proteins is minimum.
Experiments using the in vitro model-circuit revealed that the adsorption of bilirubin from the blood to Ionex was 2 to 3 times more than that to the conventional activated charcoal beads used for the treatment of hepatic cans. Sixty-six percent of conjugated bilirubin and 47% of unconjugated bilirubin was removed from the blood after in vitro 2-hour perfusion with the heparinized whole blood obtained from the jaundiced dogs.
Extracorporeal circulation with Ionex oolumn was performed using 9 dogs which were previously jaundiced by ligation of the choledochus. Removal rage of direct an indirect bilirubin after 2-hour direct heroperfusion using Ionex column (30gm) ranged fran 60 and 56% maximun to 8 and 0%m ninum respectively. These wide ranges of difference in bilirubin removal rates among the in vivo experiments were related to the severity of blood clot formation within the Ionex column.
Methods to prevent platelet adhesion to the surface of Ionex is being investigated.