A group of polyion complexes(PICs) is one of candidates for non-thrombogenic materials. In this paper, we report our recent results on the interaction between various types of PIC and blood components (plasma proteins, platelets), which play an influential role in the course of thrombus formation, with the use of our newly developed methods2, 3, 5.
The behavior of proteins and platelets on PIC coated surface was significantly influenced by molecular structure of PIC. The degree of aggregation and metamorphosis of adhered platelets was observed to relate with the degree of conformational change of adsorbed albumin.
Among the PICs examined, our newly synthesized PIC, P(p-QEAS)-PSSS, showed most promising properties for biomedical use.
