As previously reported, our newly synthesized polyion complex, P (p-QEAS) -PSSS, had promising blood-compatibility1.
In order to develop blood-compatible adsorbent for direct haemoperfusion, beads type activated charcoal was coated with P (p-QEAS) -PSSS. After coating with P (p-QEAS) -PSSS, release of carbon fines from the charcoal was markedly decreased. Adhesion of platelets was also suppressed especially when polyanion-rich P (p-QEAS) -PSSS was used as coating material.
With the use of high-speed liquid chromatography, adsorption of multi-solutes from serum by the uncoated and the coated charcoals was able to estimate. It was found that the coated charcoal had the same solute-adsorbing ability as the uncoated charcoal.
