With the development of cell transfusion therapy and hybrid-type artificial organs, needs for new materials used in cell-separation and cell-culture are amply realized. In this respect, we investigated the interaction of synthetic polymer membranes with blood cells, involved erythrocytes, leukocytes, lymphocytes, and platelets, by using “column method”. Following results are obtained: (1) Membrane properties of three kinds of blood cells are different from one another, and so, separation based on adhesion might be possible. (2) Both adhesion and metamorphosis of platelets can be controlled on the synthetic membrane having weakly cationic domains (SAx). (3) Cell adhesion is significantly affected by species, distribution, conformation, and orientation of proteins adsorbed on synthetic membranes.
