Polymers which have microphase separated structure on its surface show good antithrombogenecity. However, the role of microdomains on thrombogenesis, especially platelet adhesion and aggregation has not yet been investigated. We have synthesized block or graft copolymers composed of 2-hydroxyethyl methacrylate (HEMA) and styrene chains, and block copolymers composed of HEMA and dimethyl siloxane chains, which exibited microphase separated structures. Using these polymers, interaction between polymers and platelets were investigated with regard to influence of 1. shape, 2. size and 3. chemical structure of microdomains on platelet adhesion. As to these three factors, the most appropriate microphase separated surface was implied. These investigation suggested the possibility of controlling cell adhesion and deformation by means of domain regulation.
