1964 Volume 19 Issue 11 Pages 443-446
It was demonstrated in the author's 1 st report that DNA fraction isolated from Vibrio parahaemolyticus had lethal toxic effect to mice. In this report the immuno-serological studies on the DNA isolated from Vibrio parahaemolyticus were carried out. Purified DNA derived from Vibrio parahaemolyticus was injected intramuscularly to rabbits with complete adjuvant. High anti-DNA fraction titer was demonstrated by sensitized haemaggulutination reaction. The pretreatment by immunized rabbit serum with DNA fraction was found to have remarkable protective action against the challenge of 10 times doses of toxic fraction and remarkable protective effect against infection with Vibrio parahaemolyticus. These immuno-serological results also suggest that DNA derived from Vibrio parahaemolyticus might have a significant role.
