1968 年 23 巻 1 号 p. 13-17
1. By the procedure of transferring cultures to medium containing 50% of ox bile, the bile-tolerant strains of Lactobacillus and Streptococcus could be made after 15th passage.
2. The variants were more tolerant to sodium cholate, sodium taurocholate, sodium glycocholate and sodium desoxycholate, respectively, than their parent strains.
3. It was considered that the variants were more tolerant to bile salts of human being than their parent strains.