Technical aspects of computer-assisted magnetic resonance (MR) image-guided surgery are discussed with highlighted applications. The applications presented with clinical feasibility studies include multi-modality image registration for prostate cancer biopsy, organ deformation tracking for craniotomy, thermal monitoring for interstitial laser ablation therapy of brain tumor. A preliminary study of MR-compatible surgical manipulator is also reported. The clinical feasibility study of computer-assisted MR-guided surgery suggested the its potential contribution to accuracy, less-invasiveness, efficacy in surgical procedures.