The development of artificial blood had been proceeded through the development research of the artificial oxygen carrier: TRM-645 to substitute for the blood transfusion. We have developed the liposome encapsulated hemoglobin that have superior function for oxygen transport which was close to red blood cell as the biomimetics-technology of red blood cell. The function of oxygen transport was designed which the P50 value was controlled to 40-50 torr to use the inositol-hexaphosphate as an allosteric effector. The oxygen transporting efficiency of TRM-645 under respiration with 30-50% oxygen was superior to that of human red blood cells (hRBC). The development of the artificial oxygen carrier will be able to evolve to aim at the treatment for the stroke and the myocardial infarction as oxygen infusion liquid from the blood substitution in future. So, development of the function design will change from the blood substitution to the therapeutic purposes.
