It was discussed over the production of experimental inflammation and the effects of anti-inflammatory agents on it.
1. It is necessary to use many models or to use pathophysiologically similar model to human disease, because only a few information can be introduced from a simple experimental model.
2. Total anti-inflammatory response may be involved in the depressant action on the central nervous system as well as local anti-inflammatory response.
3. Since there was some discrepancy between the effectiveness of anti-inflam-matory agents in vivo and in vitro, the results obtained from the in vitro studies could not fully explain the mechanism of anti-inflammatory action.
4. A further developmental direction with anti-inflammatory agents would exsist in inhibition of the primary reaction of inflammation and in drug capable of a mild inhibition of the secondary reaction of inflammation.
