Abstract
The concentrations of cinepazide in human plasma and urine were studied byusing high-performance liquid chromatography. Each of 7 healthy, male volunteersreceived 200 and 400 mg of cinepazide on separate occasions for single doseexperiments. In the case of the 200 mg single dose, a rapid peak of plasma concentrationat2.8-4.9μg/ml was observedat 1-3hr, and 57.6% of the cinepazidewas excreted in urine within 24 hr. The peak plasma level increased proportionallywith the dose of cinepazide, whereas the extent of cinepazide excretionincreased slightly with the dose.
In multiple dose experiments, each of these volunteers received, on two separateoccasions, 200 mg of cinepazide t. i. d. at 9: 00 am, 1: 00 pm and 5: 00 pm eachday for 1 day and 5 days, respectively. The results on the peak and valley plasmalevels of multiple dose cinepazide indicated reproducible absorption in comparisonwith values predicted using a computer program describing a one compartment, open pharmacokinetic model. The extent of cumulative urinary excretion ofcinepazide was nearly constant during multiple dose experiments . No side effectswere noted.
