Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Online ISSN : 1882-8272
Print ISSN : 0388-1601
Evaluation of Effects of Analgesics using Electrical Stimulation on the Forefinger of Healthy Volunteers
Takashi SEKI
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1979 Volume 10 Issue 3 Pages 305-312

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Abstract

The effects of analgesics were studied in 85 healthy male volunteers between the ages of 20 and 25. Electrical stimulation was applied for 5 sec under a single blind method at a frequency of 400 Hz, width of 0.1 msec and electrical potential of 25, 35 and 55 volts on the forefinger of the subjects. Placebo, 250 mg, 500 mg and 1, 000 mg of acetylsalicylic acid, 500 mg and 1, 000 mg of phenacetin, 100 mg and 200 mg of aminopyrine, 125 mg, 250 mg and 500 mg of mefenamic acid, 12.5 mg and 25 mg of pentazocine, 50 mg and 100 mg of phenobarbital and 100 mg of phenobarbital in combination with 100 mg or 200 mg of aminopyrine were administered orally under a double blind method.
The severity of pain evoked by stimulation at 55 volts was assessed and rated on a scale according to the method of Houde et al.
As a result of this study, it was found that acetylsalicylic acid in a dose of 500 and 1, 000 mg, mefenamic acid in a dose of 250 and 500 mg, pentazocine in a dose of 25 mg and phenobarbital in a dose of 100 mg in combination with aminopyrine at 200 mg were effective in relieving pain statistically significant differences from a placebo, and that the analgesic effect of acetylsalicylic acid was prompt in onset and of short duration, whereas an effect of pain relief of pentazocine was slow in onset and long in duration.

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