FK235の臨床薬理学的検討

錠剤での検討

抄録

Plasma concentrations after FK235 4 mg tablets in single administration were measured for 6 healthy male volunteers.
The absorption of the tablet was slightly delayed in comparison with the soft capsule, and the plasma concentration after dosing with the tablet was slightly lower than with soft capsule but no significant difference.
Further, a multiple-dose trial of the FK235 tablet (14 days) with 9 healthy male volunteers was performed to investigate the tolerance and pharmacodynamics. Mild and transient clinical symptoms such as facial flush and headache were encountered in the multiple-dose trial. FK235 caused a slight decrease in diastolic blood pressure but virtually no effect on systolic blood pressure.