臨床薬理
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
Treadmill運動負荷試験による狭心症患者の運動耐容能に対するNitroglycerinテープ (NT-1) の効果
ISDNテープを対照とした二重盲検比較試験
廣沢 弘七郎谷口 興一関口 守衛本田 喬廣江 道昭神原 啓文田中 恒男
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1986 年 17 巻 4 号 p. 707-717

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The efficacy and usefulness of the nitroglycerin tape preparation NT-1 (5 mg of nitroglycerin) under treadmill exercise testing were studied by a multicenter doubleblind trial in 24 patients with stable effort angina pectoris, and compared to the results with ISDN (isosolbide dinitrate) tape (40 mg of ISDN). The patients were randomly divided into two groups (NT-1 group: 12 patients, ISDN group: 12 patients). The treadmill exercise was performed according to the Bruce protocol both before and 4 hours after administration of the tapes, and the work tolerance was determined . The results are summarized as follows: (1) The first day's data only could be utilized to compare the two groups, because a carryover effects on work tolerance was noted in the NT-1 preceeded group (P<0.05).(2) Work tolerance was significantly increased in the NT-1 group as compared with that in the ISDN group (P<0.001), and also the duration of tolerable work was significantly improved. Improvement of the duration was 91.7% in the NT-1 group and 41.7% in the ISDN group, respectively. The NT-1 rate was significantly superior (P<0.05).(3) Evaluation of the usefulness of the drugs was studied, giving a ratio of 2: 1 for the duration rate of tolerable work and the change of ST deviation in ECG. NT-1 was significantly superior to ISDN (P<0.05).
(4) A significant decrease in systolic pressure (P<0.05) and a significant increase in heart rate (P<0.001) at the end of the exercise was observed in the NT-1 group before and after administration, whereas these parameters remained unchanged in the ISDN group.(5) No side effects such as headache, hypotension, or dermal symptoms were noticed in the two groups throughout the trial .
These results indicate that NT-1 more effective than ISDN concerning work tolerance in patients with effort angina pectoris, although both NT-1 and ISDN tapes are considered to be useful.

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