Abstract
Hemolytic-uremic syndrome (HUS) is a main cause of acute or chronic renal failure in childhood, but, its treatment has not been established. We treated 8 years old boy taking HUS with the plasma exchange (PE) used plasma separator MA 2500 (ASAHI) and fresh frozen plasma. After the PE therapy, plasma FDP decreased, gross hematuria ceased, thrombocytopenia improved gradually. But, the decrease of urine FDP and proteinuria was mild, the urine volume increased, a little, and he went to regular hemodialysis terminally. These results suspect the probability that the PE therapy prevents the formation of thrombi in the afferent arterioles and capillaries of the renal glomeruli, which would be the primary lesions of the HUS. The reason why he could not recover completely from his impaired kidney function with PE therapy is probably the delayed start of the PE therapy. Therefore, it needs further studies whether early PE therapy for the HUS will meet with better outcomes.
