Determination of guanidino compounds in the plasma filtrate of hemodialysis patients

Abstract

For the purpose of evaluating the availability of plasma ultrafiltrate sampled during dialysis as analytical specimens, several chemical subutances in ultrafiltrate were measured and compared with their levels in plasma. In all substances including each guanidino compounds, A estimated value calcurated from ultrafiltrate levels and clearance levels was found to be highly correlated with actual levels in plasma.
This study has demonstrated that plasma ultrafiltrates directly sampled from dialyzers are suitable as analytic specimens instead of blood samples in practical clinical laboratories.