Abstract
A sixtyfour-year-old woman on maintenance hemodialysis diveloped bilateral facial palsies which recovered after HDF (hemodiafiltration). Eight months later, she began to show a disturbance of recentmemory and an inability to concentrate. She underwent HDF again and these neurological symptoms were ameliorated. Several determinations of serum aluminium were done but it was not increased appreciably, however the titer of IgG antibody against Borrelia burgdorferi was increased as much as 800-fold over that of the control using the immunoperoxidase method. The titers were decreased by HDF and the clinical symptoms of encephalopathy were also correlated with these titers. Taken together, this encephalopathy was probably due to a late complication of Lyme disease (stage 3).