Abstract
We assessed the timing of withdrawal of continuous intravenous infusion of glyceol to prevent dialysis-induced hypotension (DIH). Three patients on hemodialysis (HD) undergoing continuous intravenous infusion of glyceol during HD at a rate of 100ml/hr (continuous period) were selected. After all patients had been dialyzed thirty times by the above method, they were dialyzed thirty times with continuous infusion of glyceol, stopping 30 minutes (30-minute period) and 60 minutes (60-minute period) before the end of HD. In the continuous period, thirst developed as a result of increased plasma osmolality due to elevation of the serum glycerol concentration. Thirst did not develop during the 30-minute period because of significant decreases in plasma osmolality and serum glycerol concentration, in comparison with the continuous period. In addition, there was no significant difference between blood pressure levels in the continuous period and the 30-minute period. In 60-minute period, plasma osmolality and serum glycerol levels were significantly lower than in the 30-minute period, however, blood pressure in one of three patients was significantly decreased. This suggests that continuous intravenous infusion of glyceol to prevent DIH should be stopped 30 minutes before the end of HD.
