Abstract
In order to elucidate the clinical utility of bone mineral quantitation by computed X-ray densitometry (CXD) in patients with renal osteodystrophy (ROD), we investigated the correlation between ∑GS/D, MCI measured by CXD and bone mineral densities (BMDs) by dual energy X-ray adsorptiometry (DXA) in the whole body and 10 regions (head, R, L-arms, R, L-ribs, thoracic spine, lumbar spine, pelvis, R, L-legs), and the correlations between ∑GS/D, MCI, BMDs and clinical parameters related to bone metabolism (duration of dialysis therapy, serum PTH-c, Al, ALP, ALP3, BGP, TRACP) in 125 men on hemodialysis.
In addition, changes in bone mineral values by bone densitometry were observed for a year in 63 patients, and for two years in 32 patients.
1) ∑GS/D, MCI by CXD and BMDs in the whole body and the 10 regions by DXA were significantly correlated. The correlation coefficient was largest in the arms. 2) ∑GS/D was correlated with duration on dialysis therapy, serum Al, ALP, ALP3 and TRACP. 3) The mean values for the change in ∑GS/D for both one year and two years were very similar to those of BMD in the arms. 4) The percentage change in ∑GS/D for one year was correlated significantly with the change in BMD of the whole body. 5) The 32 patients observed for two years were divided into two groups, 18 patients in which PTH-c<5ng/ml (group A), and 14 patients in which PTH-c≥5ng/ml (group B). ∑GS/D in group B was significantly lower than in group A at the start of observation year and further significantly reduced after two years, but not in group A.
These results indicate the clinical utility of bone mineral quantitation by CXD in patients with ROD, and show that characteristics of ∑GS/D is similar to that of BMD in the arms by DXA.
