2009 Volume 24 Issue 6 Pages 405-410
Promotion of appropriate use of antimicrobial agents is one of the most important problems in nosocomial infection control. Our institution started a restriction program for broad-spectrum antimicrobial agents (fourth-generation cephalosporins, carbapenems, quinolones, and anti-MRSA agents) from April 2006. As a result, the consumption of fourth-generation cephalosporins and carbapenems decreased, and prescription of chronic medication lasting for 14 days or more also decreased. Moreover, we began the distribution of materials concerning antimicrobial use based on pharmacokinetics/pharmacodynamics properties in April 2008. Since then, the mode of administration of 1000 mg×3 times/day and 2000 mg×twice/day has increased for cefozopran (CZOP) and the mode of administration of 500 mg×3 times/day has increased for meropenem (MEPM). The drug-resistance rate to CZOP of Pseudomonas aeruginosa increased temporarily compared with 2005 in 2006, but recovered to the same level compared with 2005 in 2007. Moreover, the drug-resistance rate to MEPM of P. aeruginosa decreased every year. Therefore, positive intervention by the infection control team is important for promotion of appropriate antimicrobial use and preventing increase in drug resistant bacteria.
