Comparison of the Solubilities of Vancomycin Hydrochloride Products in Saline

Abstract

  Various additives are present in brand-name and generic products of vancomycin injections, which may affect their solubilities. The present study investigated the solubilities of 5 products in saline by measuring the number of insoluble microparticles with a Z1 Coulter Particle Counter based on the Coulter principle. The number of insoluble microparticles significantly decreased after shaking for a prolonged period of time in 4 products. The number of insoluble microparticles was significantly lower in one generic product than in a brand-name product. Significant differences were observed in the number of insoluble microparticles between the 5 products at solution time. Therefore, medical staff should be informed of the correct solution times which may differ between products.