2021 Volume 36 Issue 2 Pages 117-122
The guidelines recommended formulary restriction and pre-authorization and prospective audit and feedback. In Japan, there are some reports of intervention and feedback for all injectable antibiotics from large hospitals, but none from middle-sized hospitals. This study aimed to assess the impact of prospective audit and feedback for all injectable antibiotics of antimicrobial stewardship (AS) pharmacists in changes of antibiotic agents in middle-sized hospitals. The days of therapy per 1,000 patient-days (DOT/1000pd) of all injectable antibiotics significantly decreased from 248.6 to 217.1 (12.7%) after intervention. Furthermore, DOT/1000pd of anti-pseudomonas agents significantly decreased from 60.0 to 35.5 (40.8%). All antibiotic costs were reduced by about 50,000 yen (18.4%) monthly. A hospital policy to optimize antimicrobial prescription introduced by AS pharmacists decreased antibiotic consumption, especially wide-spectrum agents.