末梢性眩暈症の一家系
眩暈症とHLA
1980 年 39 巻 1 号 p. 54-58
詳細
1980 年 39 巻 1 号 p. 54-58
A patient with Ménière's disease whose younger brother and two children had positional vertigo of benign paroxysmal type is presented. The family history and other reports on paroxysmal vertigo suggest the possibility that paroxysmal vertigo may be inherited in some cases.
To evaluate the relationship between paroxysmal vertigo and heredity, we studied the association between paroxysmal vertigo (Ménière's disease, P.V.B.P) and HLA (Human Leucocyte Antigens).
Twenty-eight patients were typed for HLA-A, B or C locus by the lymphocyte toxcitity test. HLA-Bw16 was found in 27.8 per cent of the Ménière's disease cases (N=18) as compared to 9.3 per cent in the controls (N=215) and the relative risk was 3.75 (P<0.05).
