塩酸エペリゾンの内耳への影響

抄録

Electrophysiological studies were performed on guinea pigs to elucidate the mechanism underlying the antivertigo action of eperisone, an antispastic drug. Nystagmus was observed when eperisone was introduced into the middle tympanic cavity via the external auditory meatus. The attitudes of the nystagmus induced were similar to those of nystagmus induced by lidocaine. The effect on hearing was a temporary moderate hearing loss, which almost completely disappeared in time. Eperisone was found to effectively anesthetized and suppress irritability in the inner ear. These effects are thought to be related to eperisone's antivertigo actions.