スコポラミンの自律神経系への効果 第2編

サーモグラフィーによる検討

抄録

The authors have previously reported a study in which autonomic function was evaluated by thermography in an examination of the effect of transdermal scopolamine (TTS scopolamine) on the autonomic nervous system. We found that TTS scopolamine inhibits vestibular autonomic reflexes but does not af-fect the somatic autonomic reflex system. In the present study, we tested the effect of TTS scopolamine on the response to caloric stimulation, metopic cooling stimulation, podalic cooling stimulation and on un-stimulated CV %. The results showed that only in caloric stimulation the amplitude of the cutaneous temperature variation significantly reduced after the dermal application of TTS scopolamine. No significant temperature differences were noted with metopic cooling stimulation, podalic cooling stimulation or un-stimulated CV %.
Thus, as in the previous study, the results indicate that the TTS-scopolamine inhibits vestibular reflexes but does not affect the somatic reflex system. The present results also suggest that inhibitory effects no the pathway from the medullary respiratory control centers to the endings of vagal efferent fibers are slight.