中枢前庭代償への内在性グルココルチコイドの関与
前庭代償とグルココルチコイド
1995 年 54 巻 4 号 p. 354-358
詳細
1995 年 54 巻 4 号 p. 354-358
A behavioral study was performed to examine the effect of glucocorticoid agonist (dexamethasone) and glucocorticoid receptor antagonist (RU38486) on the vestibular compensation following unilateral labyrinthectomy in pigmented young rabbits. The frequency of spontaneous nystagmus and the angle of head deviation were both reduced markedly in the rabbits treated with 1 or 5 mg/kg intravenous dexamethasone compared with the controls treated with saline. In contrast, intramuscular RU38486 retarded improvement of the vestibular symptons. These results suggest that endogenous glucocorticoids contribute to the achievement of the vestibular compensation.
