抄録
Cytochrome P450 (CYP) multiple enzyme system plays a major role in oxidative metabolism of a broad variety of endogenous and exogenous compounds, including sterols, fatty acids, drugs and xenobiotics. Some CYP isozymes are known to be induced by xenobiotics, including environmental pollutants. In order to estimate the suitability of using CYP as indicator of environment, we have been investigated about the CYP-dependent activities in hepatic microsomes of feral rodent (Clethrionomys rufocanus) and marine mammal (Phoca largha). From the results of our investigations, it can be concluded that the CYP-dependent activities are useful biomarkers of environmental pollution.
