1980 Volume 15 Issue 1 Pages 7-16
The pharmacokinetic and residual examinations of erythromycin(EM)were studied in cultured yellowtails Seriola quinqueradiata orally administered a single or multiple dose (s) of 50mg/kg/day with the following results.
Orally administered EM produced peak levels in blood and tissue 1 to 3 hr post dosing and the levels in liver, kidney and spleen were about 4 times as high as that in blood.The level in muscle was approximately equal to that in blood.
A single dose of EM produced blood and tissue levels which were 10 to 100 times as high as the MIC for Streptococcus sp.1 hr post dosing, and higher levels than the MIC were detected 24 hr following administration.
Blood and tissue levels of EM after 10 consecutive administrations were almost same or slightly higher than those obtained by the single administration, though their distribution patterns were similar.
After the withdrawal of 10 consecutive dosing, levels of EM in blood and tissue decreased exponentially, and biological half-lives were blood;5.00-7.78hr, liver;8.37-9.75hr, kidney;14.80-15.63hr, spleen;14.32-15.89 hr, muscle;7.15-8.17hr. A level below the assay limits(0.03-0.08μg/ml or g)was reached 144-168 hr post dosing.
No evidence of long term residue was found in any of the tissues tested.
